Cowchock F S, Gibas Z, Jackson L G
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Fertil Steril. 1993 May;59(5):1011-4. doi: 10.1016/s0015-0282(16)55920-2.
To evaluate the likelihood of obtaining a chromosome diagnosis in cases of spontaneous abortion (SAB) and of the relative importance of maternal age versus obstetric history in predicting the fetal karyotype.
Obstetric history was obtained from all 100 cases of miscarriage in 1 year when products of conception were sent for chromosome studies. Multiple logistic regression analysis was used to calculate odds ratio and statistical significance for correlations between historical factors and the probability of any chromosomal abnormality or trisomy.
A chromosome diagnosis was made in 84% of cases. Maternal age was a more important predictor of chromosome abnormality, specifically trisomy, than history of previous livebirths or miscarriages.
Results from chromosome studies using chorionic villi from SABs are diagnostically useful, even when the patient has a history of repeated miscarriages.
评估自然流产（SAB）病例中获得染色体诊断的可能性，以及母亲年龄与产科病史在预测胎儿核型方面的相对重要性。
从1年内100例流产病例中获取产科病史，这些病例的妊娠产物被送去进行染色体研究。采用多元逻辑回归分析来计算历史因素与任何染色体异常或三体发生概率之间相关性的比值比和统计学意义。
84%的病例获得了染色体诊断。母亲年龄比既往活产或流产史更能预测染色体异常，特别是三体。
即使患者有反复流产史，利用自然流产绒毛进行染色体研究的结果在诊断上也是有用的。
