Schneider M A, Davies M C, Honour J W
University College and Middlesex School of Medicine (UCMSM), Middlesex Hospital, London, United Kingdom.
Fertil Steril. 1993 May;59(5):1059-64. doi: 10.1016/s0015-0282(16)55928-7.
To test the timing of placental support of pregnancy.
Steroid levels in blood and urine were determined in pregnancy after ET into women with ovarian failure.
The study was carried out in a private IVF clinic and a university endocrine department.
Four patients with ovarian failure were treated by IVF using donor oocytes.
Estrogen and P were given, up to the point of ET, to achieve the hormonal levels in the ranges for normal menstrual cycles. Pregnancy was supported in the first trimester by exogenous steroids.
The four pregnancies went to term, and each resulted in singleton livebirths.
Increases in plasma P concentrations and in urinary pregnanediol excretion rates were indications for a placental contribution to the hormone pool.
One hundred mg of P were probably a supraphysiological dose to support pregnancy 6 to 8 weeks after conception. The fetoplacental unit was competent from 10 to 12 weeks' gestation.
检测胎盘对妊娠的支持时机。
对卵巢功能衰竭女性进行胚胎移植（ET）后，测定其血液和尿液中的类固醇水平。
该研究在一家私立体外受精诊所和一所大学内分泌科进行。
4名卵巢功能衰竭患者接受了使用供体卵母细胞的体外受精治疗。
在ET前给予雌激素和孕酮，以使激素水平达到正常月经周期范围。孕早期通过外源性类固醇维持妊娠。
4例妊娠均足月，且均为单胎活产。
血浆孕酮浓度升高和尿孕二醇排泄率增加表明胎盘对激素池有贡献。
100mg孕酮可能是受孕后6至8周维持妊娠的超生理剂量。胎儿-胎盘单位在妊娠10至12周时功能正常。
