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[突变过程的温度修饰与热休克蛋白]

[Temperature modification of the mutation process and heat shock proteins].

作者信息

Tikhomirova M M, Mazur E L, Barabanova L V, Mamon L A

出版信息

Genetika. 1993 Feb;29(2):280-7.

PMID:8486258
Abstract

Heat shock protein synthesis and mutagenesis (X-chromosome losses induced by radiation and high temperature) were studied in different. Drosophila melanogaster strains. Two models (strain l(1)ts403 with the defect in heat shock protein synthesis and the heat-resistant T strain with a specific reaction to the extreme temperature differing from the wild type strains) were used. The correlation between heat shock protein synthesis and the effect of synergism in the action of radiation and heat shock was revealed. It was concluded that HSPs are one of the components in mutagenic processes.

摘要

研究了不同黑腹果蝇品系中的热休克蛋白合成与诱变作用(辐射和高温诱导的X染色体缺失)。使用了两种模型(热休克蛋白合成存在缺陷的品系l(1)ts403和对极端温度有不同于野生型品系的特定反应的耐热T品系)。揭示了热休克蛋白合成与辐射和热休克联合作用中的协同效应之间的相关性。得出的结论是,热休克蛋白是诱变过程中的组成部分之一。

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