Irwin M J, Hudson K R, Ames K T, Fraser J D, Gascoigne N R
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Immunol Rev. 1993 Feb;131:61-78. doi: 10.1111/j.1600-065x.1993.tb01530.x.
The last few years have seen an enormous jump in our knowledge and understanding of T-cell activation by superantigens. Clearly, a great number of infectious and parasitic organisms utilize superantigens as part of a strategy to evade the immune response of their host. The ability to modulate superantigen effects will give us new means to fight infections, and the knowledge of T-cell activation that we have gained from study of superantigens will, in turn, allow us to modulate the immune system in new ways.
在过去几年里，我们对超抗原激活T细胞的认识和理解有了巨大飞跃。显然，大量的传染性和寄生性生物体利用超抗原作为逃避宿主免疫反应策略的一部分。调节超抗原效应的能力将为我们提供对抗感染的新手段，而我们从对超抗原的研究中获得的T细胞激活知识，反过来又将使我们能够以新的方式调节免疫系统。
