Scragg J N, Proctor E M
Am J Trop Med Hyg. 1977 Mar;26(2):198-203. doi: 10.4269/ajtmh.1977.26.198.
Mebendazole (methyl-5-benzoylbenzimidazole-2-carbamate), a new broad spectrum anthelmintic, cured 26 (74% out of 35 children) with severe symptomatic trichuriasis. Repeat course of therapy were necessary in some cases. The nine treatment failures all showed large reductions (82-99%) in egg counts. Thus, an overall satisfactory response was obtained in terms of complete parasite eradication in 74%, relief of symptoms in all, and significant reduction in worm load in the failures. In the recommended dosage of 100 mg twice daily for 3 days mebendazole failed to achieve a cure rate of 95% to 100% reported in asymptomatic individuals and those with light infections of Trichuris trichiura. It is probable that measures to control diarrhea before administering mebendazole in an increased, extended, or repreated dosage schedule will achieve a higher cure rate. The drug was well tolerated and completely free from any toxic effects.
甲苯咪唑（5-苯甲酰基苯并咪唑-2-氨基甲酸甲酯）是一种新型广谱驱虫药，治愈了26例（35名儿童中的74%）重度有症状鞭虫病患者。在某些情况下需要重复疗程治疗。9例治疗失败的患者虫卵计数均大幅下降（82%-99%）。因此，总体而言，在74%的患者中实现了完全清除寄生虫，所有患者症状得到缓解，治疗失败患者的虫负荷显著降低，取得了令人满意的效果。按照每日两次、每次100毫克、共服用3天的推荐剂量，甲苯咪唑未能达到无症状个体和轻度鞭虫感染患者报告的95%至100%的治愈率。在增加剂量、延长疗程或重复给药方案的情况下，在服用甲苯咪唑前采取控制腹泻的措施可能会获得更高的治愈率。该药物耐受性良好，完全没有任何毒性作用。
