甲苯达唑治疗儿童症状性鞭虫病的更多经验。

Further experience with mebendazole in the treatment of symptomatic trichuriasis in children.

作者信息

Scragg J N, Proctor E M

出版信息

Am J Trop Med Hyg. 1978 Mar;27(2 Pt 1):255-7. doi: 10.4269/ajtmh.1978.27.255.

DOI:10.4269/ajtmh.1978.27.255

Abstract

Mebendazole (methyl-5-benzoylbenzimidazole-2-carbamate: Vermox), a broad spectrum anthelmintic, cured 22 (88%) children with symptomatic trichuriasis when given as a single 6-day course in a dosage of 100 mg twice daily. A further 3 (12%) were cured after a repeat 6-day course of therapy. Thus complete parasite eradication was achieved in all. The administration of an antidiarrheal agent, loperamide hydrochloride (Imodium), appeared to enhance the efficacy of mebendazole. Both drugs were well tolerated and completely free of any toxic effects.

摘要

甲苯咪唑（5-苯甲酰基苯并咪唑-2-氨基甲酸甲酯：肠虫清）是一种广谱驱虫药，以每日两次、每次100毫克的剂量单次服用，进行为期6天的疗程，治愈了22名（88%）有症状的鞭虫病儿童。在重复进行6天的治疗疗程后，又有3名（12%）儿童被治愈。因此，所有儿童均实现了寄生虫的完全根除。给予止泻药盐酸洛哌丁胺（易蒙停）似乎可提高甲苯咪唑的疗效。两种药物耐受性良好，完全没有任何毒性作用。