Johnson W C, Patten D H
Am J Surg. 1977 Apr;133(4):485-9. doi: 10.1016/0002-9610(77)90136-2.
In a prospective study of twenty-six patients with ischemic ulcerations of the lower extremity, the predictive reliability with regard to spontaneous wound healing of diabetes, pedal pulses, ankle blood pressure (ABP) as measured by doppler ultrasound, and "leg ulcer scan" as performed by the intra-arterial injection of radioactive albumin was evaluated. The results suggest that only the leg ulcer scan is significantly reliable in predicting the likelihood of spontaneous healing. The following format for the evaluation of the ischemic leg ulcer is therefore suggested: (1) If pedal pulses are present, a three week trial of conservative therapy is indicated before further evaluation. (2) If the doppler ABP is 50 mm Hg or less, the ulcer will not heal spontaneously. (3) Leg ulcer scan is indicated: (a) in the absence of pedal pulses if ABP is less than 50 mm Hg; (b) in the presence of pedal pulses if there is no evidence of spontaneous healing after three weeks of conservative therapy.
在一项针对26例下肢缺血性溃疡患者的前瞻性研究中，对糖尿病、足部脉搏、通过多普勒超声测量的踝部血压（ABP）以及通过动脉内注射放射性白蛋白进行的“腿部溃疡扫描”与自发伤口愈合的预测可靠性进行了评估。结果表明，只有腿部溃疡扫描在预测自发愈合可能性方面具有显著可靠性。因此，建议采用以下格式评估缺血性腿部溃疡：（1）如果存在足部脉搏，在进一步评估之前应进行为期三周的保守治疗试验。（2）如果多普勒ABP为50毫米汞柱或更低，溃疡将不会自发愈合。（3）指示进行腿部溃疡扫描：（a）在无足部脉搏且ABP小于50毫米汞柱的情况下；（b）在有足部脉搏且经过三周保守治疗后无自发愈合迹象的情况下。
