De la Sota R L, Lucy M C, Staples C R, Thatcher W W
Dairy Science Department, University of Florida, Gainesville 32611-0920.
J Dairy Sci. 1993 Apr;76(4):1002-13. doi: 10.3168/jds.S0022-0302(93)77428-7.
Metabolic and ovarian responses of lactating and nonlactating cows to recombinant bST (sometribove) were measured. Eighteen lactating cows (60 to 100 d postpartum) and 6 nonlactating cows (> 400 d postpartum) were injected daily with bST or saline during one of two periods. Concentrations of hormones and metabolites were measured in plasma, and ultrasonography was used to quantify ovarian follicular growth. Concentrations of glucose, insulin, IGF-I, progesterone, and estradiol in plasma were greater in nonlactating cows than in lactating cows. Lactating cows had fewer class 2 (6- to 9-mm) and class 3 (10- to 15-mm) follicles and more class 4 (> 15-mm) follicles than nonlactating cows. Bovine somatotropin increased the numbers of follicles in lactating cows so that the numbers of class 2 and of class 3 follicles were equivalent to those for non-lactating cows. Sizes of the largest follicles were similar for bST-and saline-treated cows. The second largest ovarian follicles, however, were larger in bST-treated cows. Ovarian follicular dynamics were altered by bST and lactation. Bovine somatotropin increased the numbers of follicles (6 to 15 mm) in lactating cows and size of second largest ovarian follicles in both lactating and nonlactating cows. Lactating cows developed dominant follicles that were larger and less estrogenic than those of nonlactating cows.
测定了泌乳期和非泌乳期奶牛对重组牛生长激素（sometribove）的代谢和卵巢反应。在两个时间段之一，对18头泌乳期奶牛（产后60至100天）和6头非泌乳期奶牛（产后>400天）每天注射牛生长激素或生理盐水。测定血浆中激素和代谢物的浓度，并使用超声检查来量化卵巢卵泡的生长。非泌乳期奶牛血浆中葡萄糖、胰岛素、胰岛素样生长因子-I、孕酮和雌二醇的浓度高于泌乳期奶牛。与非泌乳期奶牛相比，泌乳期奶牛2级（6至9毫米）和3级（10至15毫米）卵泡较少，4级（>15毫米）卵泡较多。牛生长激素增加了泌乳期奶牛的卵泡数量，使2级和3级卵泡数量与非泌乳期奶牛相当。接受牛生长激素和生理盐水处理的奶牛最大卵泡大小相似。然而，接受牛生长激素处理的奶牛第二大卵巢卵泡更大。牛生长激素和泌乳改变了卵巢卵泡动态。牛生长激素增加了泌乳期奶牛卵泡（6至15毫米）的数量，以及泌乳期和非泌乳期奶牛第二大卵巢卵泡的大小。泌乳期奶牛发育出的优势卵泡比非泌乳期奶牛的更大且雌激素含量更低。
