Sakata H, Hirano Y, Maruyama S
Department of Pediatrics, Asahikawa Kosei Hospital.
Kansenshogaku Zasshi. 1993 Mar;67(3):212-7. doi: 10.11150/kansenshogakuzasshi1970.67.212.
One hundred and seventy one neonates were treated with flomoxef (FMOX) and the clinical efficacy and safety were evaluated. The ages of the patients ranged from 0 to 28 days, and their body weights from 450 to 4300 g. Dose levels were 12.4 to 24.9 mg/kg every 8 or 12 hours for 1 to 10 days. Fifty two patients who responded to the FMOX treatment included 5 neonates with sepsis, 17 with suspected sepsis, 9 with urinary tract infections, 12 with pneumonia, 8 with intrauterine infections, and 1 with omphalitis. The other neonates could not be retrospectively diagnosed as bacterial infections. Of 52 patients, clinical results were excellent in 15, good in 34, fair in 1, and poor in 2. And the FMOX treatment was effective in 13 out of 14 patients in which causative bacteria were identified. The drug was well tolerated, but 6 neonates out of 33 over 5 days old had diarrhea. From these results, empiric treatment with FMOX against neonatal bacterial infection was as clinically useful as that of combination with ampicillin and gentamicin or cefotaxime and ampicillin in our neonatal intensive care unit. But, as this study did not include neonate with meningitis, efficacy to meningitis was not evaluated.
对171例新生儿使用氟氧头孢（FMOX）进行治疗，并评估其临床疗效和安全性。患者年龄为0至28天，体重为450至4300克。剂量水平为每8或12小时12.4至24.9毫克/千克，持续1至10天。对FMOX治疗有反应的52例患者中，包括5例败血症新生儿、17例疑似败血症患者、9例尿路感染患者、12例肺炎患者、8例宫内感染患者和1例脐炎患者。其他新生儿无法进行回顾性细菌感染诊断。52例患者中，临床结果为优的有15例，良的有34例，中平的有1例，差的有2例。在14例鉴定出病原菌的患者中，FMOX治疗对13例有效。该药物耐受性良好，但33例5日龄以上的新生儿中有6例出现腹泻。从这些结果来看，在我们的新生儿重症监护病房中，FMOX经验性治疗新生儿细菌感染在临床上与氨苄西林联合庆大霉素或头孢噻肟联合氨苄西林一样有用。但是，由于本研究未纳入患有脑膜炎的新生儿，因此未评估其对脑膜炎的疗效。
