Eyre H J, Crowley J J, Townsend J J, Eltringham J R, Morantz R A, Schulman S F, Quagliana J M, al-Sarraf M
Department of Medicine, University of Utah Medical Center, Salt Lake City.
J Neurosurg. 1993 Jun;78(6):909-14. doi: 10.3171/jns.1993.78.6.0909.
Sixty adult patients with incompletely excised low-grade gliomas were randomly assigned to receive radiotherapy (55 Gy over a total of 6 1/2 to 7 weeks) either alone or with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; 100 mg/sq m every 6 weeks). Pathological review showed that six patients were ineligible for the study. Evaluation of patient age, extent of surgery, tumor grade, and performance status showed no significant differences between the treatment arms. The response rate, as judged by the disappearance or reduction in size of the tumor on computerized tomography scans, was 79% for radiation therapy alone versus 54% for irradiation plus CCNU. The median survival time was 4.45 years for all patients, with no significant difference between treatment arms (p = 0.7). For the group as a whole, patient age and performance status were the most important prognostic parameters. The majority of patients receiving chemotherapy experienced moderate hematological toxicity. This study demonstrates that CCNU chemotherapy does not improve the results of radiation therapy in the treatment of incompletely excised low-grade gliomas.
60例低度恶性胶质瘤切除不完全的成年患者被随机分配，分别单独接受放疗（在6.5至7周内共55 Gy）或放疗联合1-(2-氯乙基)-3-环己基-1-亚硝基脲（CCNU；每6周100 mg/平方米）。病理检查显示6例患者不符合研究条件。对患者年龄、手术范围、肿瘤分级和身体状况的评估表明，各治疗组之间无显著差异。根据计算机断层扫描显示肿瘤消失或缩小来判断，单纯放疗的缓解率为79%，放疗加CCNU为54%。所有患者的中位生存时间为4.45年，各治疗组之间无显著差异（p = 0.7）。对于整个组而言，患者年龄和身体状况是最重要的预后参数。大多数接受化疗的患者出现中度血液学毒性。本研究表明，CCNU化疗并不能改善放疗对切除不完全的低度恶性胶质瘤的治疗效果。
