Trojanowski T, Peszyński J, Turowski K, Markiewicz P, Gościński I, Bielawski A, Bendarzewska B, Szymona J, Dabrowska A, Lopatkiewicz J
Department of Neurosurgery, Medical Academies, Lublin, Cracow.
J Neurosurg. 1989 Jan;70(1):18-23. doi: 10.3171/jns.1989.70.1.0018.
This prospective randomized clinical trial compared the effectiveness of combined treatment with CCNU and radiation therapy to the use of radiation therapy alone for the postoperative management of supratentorial brain gliomas (67% anaplastic) in 198 patients. The results were evaluated with the aid of a specially developed weighted neuropsychological test battery providing single-value estimation of "life quality" of patients, as well as with a clinical performance scale. Based on these methods, it was established that patients improved within 6 months following therapy. This improvement was maintained in surviving patients during the 2-year follow-up period. The patients led a relatively normal life, but when their condition deteriorated their decline was rapid. The median survival time of patients treated with radiotherapy did not differ significantly from that of patients receiving chemotherapy in addition. Nor did the analysis of life quality and of changes in clinical performance show any benefit in supplementing surgery and radiation therapy with CCNU chemotherapy at the dosage used.
这项前瞻性随机临床试验比较了CCNU与放射治疗联合应用和单纯放射治疗对198例幕上脑胶质瘤（67%为间变性）术后管理的有效性。借助专门开发的加权神经心理测试组对患者的“生活质量”进行单值评估，并结合临床表现量表对结果进行评估。基于这些方法，确定患者在治疗后6个月内病情有所改善。在2年的随访期内，存活患者的这种改善得以维持。患者过着相对正常的生活，但病情恶化时衰退迅速。接受放射治疗的患者的中位生存时间与另外接受化疗的患者相比无显著差异。对生活质量和临床表现变化的分析也未显示在所用剂量下用CCNU化疗补充手术和放射治疗有任何益处。
