Sørensen S A, Fenger K
Institute of Medical Genetics, University of Copenhagen, Denmark.
J Med Genet. 1992 Dec;29(12):911-4. doi: 10.1136/jmg.29.12.911.
Causes of death were examined from death certificates for 395 Danish subjects with Huntington's disease (HD) and for 282 unaffected sibs and compared with the causes of death in the general Danish population. For both the HD subjects and the sibs, pneumonia and cardiovascular diseases were the most frequent primary causes of death. Suicides accounted for 5.6% of all deaths among the HD subjects and, unexpectedly, for 5.3% among the sibs, some of whom may have been carriers of the HD gene. Both were significantly higher than the corresponding frequency of 2.7% in the general Danish population, but there was no evidence of differences in the age specific proportions for the HD subjects and for the sibs compared to the general population. Some accidents leading to death in the sibs may have been hidden suicides. The rate of cancer was low for the HD patients, being only 5.3% compared with 31.2% for the sibs. Neurological diseases were reported with an increased frequency in the HD patients compared to the general population, 6% v 1%.
从395名患有亨廷顿舞蹈症（HD）的丹麦人和282名未患病的同胞的死亡证明中对死因进行了调查，并与丹麦普通人群的死因进行了比较。对于HD患者和同胞来说，肺炎和心血管疾病是最常见的主要死因。自杀在HD患者的所有死亡中占5.6%，出乎意料的是，在同胞中占5.3%，其中一些人可能是HD基因的携带者。这两个比例均显著高于丹麦普通人群中2.7%的相应比例，但没有证据表明HD患者和同胞在年龄特异性比例上与普通人群存在差异。同胞中一些导致死亡的事故可能是隐蔽的自杀行为。HD患者的癌症发生率较低，仅为5.3%，而同胞为31.2%。与普通人群相比，HD患者中神经系统疾病的报告频率有所增加，分别为6%和1%。
