Kalinna B, McManus D P
Molecular Helminthology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Parasitology. 1993 Apr;106 ( Pt 3):289-96. doi: 10.1017/s0031182000075119.
Previous studies from this laboratory have suggested the presence of antibody-binding molecules on the surface of Taenia crassiceps metacestodes. We now report the purification of a T. crassiceps Fc gamma-binding protein which has an equivalent molecular size (96 kDa), is antigenically similar and exhibits significant amino acid sequence homology to schistosome paramyosin. The similarities in molecular weight of the T. crassiceps protein, Schistosoma mansoni paramyosin and antigen B of T. solium, the close amino acid sequence homologies between the T. crassiceps protein and S. mansoni paramyosin and between S. mansoni paramyosin and antigen B of T. solium, and the antigenic similarity of the T. crassiceps protein with paramyosin indicates that this family of platyhelminth proteins are closely related. The known characteristics of T. solium antigen B (collagen binding affinity; disruption of complement function) and the Fc gamma-binding activity of the T. crassiceps molecule suggests that this class of proteins may be multifunctional, fulfilling not only a structural role but also as components interacting with the host immune system to increase parasite survival.
本实验室先前的研究表明，克氏假裸头绦虫中绦期幼虫表面存在抗体结合分子。我们现在报告一种克氏假裸头绦虫Fcγ结合蛋白的纯化，该蛋白具有相同的分子大小（96 kDa），抗原性相似，并且与血吸虫副肌球蛋白具有显著的氨基酸序列同源性。克氏假裸头绦虫蛋白、曼氏血吸虫副肌球蛋白和猪带绦虫抗原B的分子量相似，克氏假裸头绦虫蛋白与曼氏血吸虫副肌球蛋白之间以及曼氏血吸虫副肌球蛋白与猪带绦虫抗原B之间的氨基酸序列紧密同源，并且克氏假裸头绦虫蛋白与副肌球蛋白的抗原性相似，这表明这类扁形虫蛋白密切相关。猪带绦虫抗原B的已知特性（胶原结合亲和力；补体功能破坏）以及克氏假裸头绦虫分子的Fcγ结合活性表明，这类蛋白可能具有多种功能，不仅起到结构作用，还作为与宿主免疫系统相互作用的成分以提高寄生虫的存活率。
