Hunder G, Nguyen P T, Schümann K, Fichtl B
Walther Straub-Institut für Pharmakologie und Toxikologie, Universität München, Germany.
Res Commun Chem Pathol Pharmacol. 1993 Apr;80(1):83-92.
The effects of organic (oxophenylarsine, PhAsO 2.5-50 mumol/l) and inorganic arsenicals (As2O3 2.5-250 mumol/l; As2O5 2.5-2500 mumol/l) on intestinal transfer of water, sodium, glucose and leucine was investigated in vitro using isolated jejunal segments of male Sprague Dawley rats. All three arsenicals decreased in a dose-dependent manner the transfer of water, sodium, glucose and leucine. At the highest concentrations investigated the amount absorbed was reduced to some 10-20% of the respective control values. For both glucose and leucine the concentration ratio between absorbate and perfusate was about 3.5-4 in controls. It decreased to about 2 for leucine and to near unity for glucose. As assessed from the concentration ratio between intestinal tissue and perfusate the arsenic compounds inhibited the uptake of glucose and leucine into the tissue. There was a marked difference with respect to the potency of arsenicals, PhAsO being about 10 times more potent than As2O3 which in turn was about 5 times more potent than As2O5.
使用雄性斯普拉格-道利大鼠的离体空肠段，在体外研究了有机砷（氧代苯胂，PhAsO 2.5 - 50 μmol/L）和无机砷（As2O3 2.5 - 250 μmol/L；As2O5 2.5 - 2500 μmol/L）对水、钠、葡萄糖和亮氨酸肠道转运的影响。所有三种砷化合物均以剂量依赖方式降低水、钠、葡萄糖和亮氨酸的转运。在所研究的最高浓度下，吸收量降低至各自对照值的约10% - 20%。对于葡萄糖和亮氨酸，对照中吸收物与灌注液之间的浓度比约为3.5 - 4。亮氨酸的该比值降至约2，葡萄糖的该比值降至接近1。根据肠道组织与灌注液之间的浓度比评估，砷化合物抑制葡萄糖和亮氨酸进入组织。在砷化合物的效力方面存在显著差异，PhAsO的效力约为As2O3的10倍，而As2O3的效力又约为As2O5的5倍。
