Fey M F
Institut für medizinische Onkologie, Inselspital Bern.
Schweiz Med Wochenschr. 1993 Apr 17;123(15):721-8.
Oncological emergencies are frequent, particularly in advanced cancer stages. Many situations can only be tackled successfully with the cooperation of a well organized team of specialists. Spinal cord compression caused by cancer requires particularly swift action. The diagnosis should include a careful neurological examination. Myelography, once a classical approach in this setting, is increasingly being replaced by nuclear magnetic imaging techniques. Steroids should be given immediately after a diagnosis has been made and further treatment includes surgery, radiotherapy and/or chemotherapy, depending on the type of tumour involved. Febrile patients with severe neutropenia due to myelosuppression by cytostatic drugs often require treatment with intravenous antibiotics. Although hematopoietic growth factors are now available to hasten neutrophil recovery, these drugs should not be given on a routine basis. Another relatively frequent emergency is the superior vena cava syndrome, which is almost always due to a malignant tumour. Any treatment plan prepared to deal with an oncological emergency in a particular patient should take into account the prognosis of the underlying disease, the prospects for further therapy, and the patient's attitude.
肿瘤急症很常见,尤其是在癌症晚期。许多情况只有在一个组织良好的专家团队的合作下才能成功解决。癌症引起的脊髓压迫需要特别迅速的行动。诊断应包括仔细的神经系统检查。脊髓造影曾是这种情况下的经典方法,现在越来越多地被核磁共振成像技术所取代。诊断一旦确定,应立即给予类固醇,进一步的治疗包括手术、放疗和/或化疗,具体取决于所涉及的肿瘤类型。因细胞毒性药物导致骨髓抑制而出现严重中性粒细胞减少的发热患者通常需要静脉注射抗生素治疗。尽管现在有造血生长因子可加速中性粒细胞恢复,但这些药物不应常规使用。另一种相对常见的急症是上腔静脉综合征,几乎总是由恶性肿瘤引起。为特定患者制定的任何处理肿瘤急症的治疗计划都应考虑基础疾病的预后、进一步治疗的前景以及患者的态度。