Dorval G, Vanky F, Klein E, Wigzell H
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):111-2.
Human sarcomas, carcinomas and brain tumours were assayed for the presence of immunoglobulins IgG. Among 16 tumours tested, 14 had detectable amount of IgG that could be released when incubated in culture conditions. Addition of iodoacetamide--a metabolic inhibitor--inhibited this " uncoating process ". The uncoated cells rebound IgG if incubated subsequently with any of the cancer sera tested. However, when the autologous serum was present during the uncoating incubation, subsequent rebinding at 4 degree C of IgG from the same or other cancer sera was significantly decreased compared to alquots pre-incubated in other sera.
对人类肉瘤、癌和脑肿瘤进行了免疫球蛋白IgG检测。在检测的16个肿瘤中，有14个含有可检测到的IgG量，当在培养条件下孵育时可释放出来。添加碘乙酰胺（一种代谢抑制剂）可抑制这种“脱壳过程”。脱壳后的细胞如果随后与任何一种检测的癌血清一起孵育，会重新结合IgG。然而，当在脱壳孵育过程中存在自体血清时，与在其他血清中预孵育的等分试样相比，4℃时来自相同或其他癌血清的IgG随后的重新结合显著减少。
