Lynch N R, Salomon J C
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):121-3.
When radiolabelled lymphoid cells and the extracellular dye Lissamine green were injected IV into C3H mice carrying non-necrotic methylcholanthrene-induced tumours, the tumour content of these agents was significantly lower than in other organs. The tumour content of these circulating blood components was significantly increased by the intratumoral (IT) induction of local passive anaphylactic reactions, and such reactions exerted an anti-tumour effect, and enhanced the therapeutic activity of IT BCG. No anti-tumour IgE antibody was detected in this model, but the tumour inhibited passive and active anaphylactic reactions in its host.
当将放射性标记的淋巴细胞和细胞外染料丽丝胺绿静脉注射到携带未坏死的甲基胆蒽诱导肿瘤的C3H小鼠体内时，这些物质在肿瘤中的含量显著低于其他器官。肿瘤内（IT）诱导局部被动过敏反应可显著增加这些循环血液成分在肿瘤中的含量，并且这种反应发挥抗肿瘤作用，并增强IT卡介苗的治疗活性。在该模型中未检测到抗肿瘤IgE抗体，但肿瘤抑制其宿主的被动和主动过敏反应。
