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[先天性无胸腺裸鼠的抗弓形虫免疫]

[Antitoxoplasmic immunity on congenitally athymic nude mice].

作者信息

Stadtsbaeder S

出版信息

Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):149-50.

PMID:848869
Abstract

Susceptibility to toxoplasmic infection was found to be the same in Nude mice (nu/nu) as in controls. Vaccination with avirlent toxoplasma (Beverley strains) confered an incomplete immunity to Nude mice: in 20 to 40% of cases, mortality was delayed as compared to unvaccinated control. Cellular (activation of macrophages) and humoral (circulating antibodies) immune responses were partially present in Nude mice.

摘要

研究发现,裸鼠(nu/nu)对弓形虫感染的易感性与对照组相同。用无毒力的弓形虫(贝弗利株)进行疫苗接种,给予裸鼠的免疫力并不完全:在20%至40%的病例中,与未接种疫苗的对照组相比,死亡时间有所延迟。裸鼠体内部分存在细胞免疫反应(巨噬细胞激活)和体液免疫反应(循环抗体)。

相似文献

1
[Antitoxoplasmic immunity on congenitally athymic nude mice].[先天性无胸腺裸鼠的抗弓形虫免疫]
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):149-50.
2
Infection of congenitally athymic (nude) mice with Toxoplasma gondii.先天性无胸腺(裸)小鼠感染刚地弓形虫。
Ann Microbiol (Paris). 1976 Nov-Dec;127B(4):503-7.
3
Respective role of antibodies and immune macrophages during acquired immunity against toxoplasmosis in mice.
Ann Immunol (Paris). 1975 Jun-Jul;126C(4):461-74.
4
[Antigens of Toxoplasma gondii with a diagnostic and potential immunoprophylactic value: new strategies of identification].[具有诊断和潜在免疫预防价值的弓形虫抗原:鉴定新策略]
Ann Biol Clin (Paris). 1989;47(7):451-7.
5
Protection of mice and nude rats against toxoplasmosis by a multiple antigenic peptide construction derived from Toxoplasma gondii P30 antigen.源自刚地弓形虫P30抗原的多抗原肽构建体对小鼠和裸鼠抗弓形虫病的保护作用。
J Immunol. 1992 Dec 1;149(11):3636-41.
6
Toxoplasmosis in nude mice.裸鼠中的弓形虫病
J Parasitol. 1977 Apr;63(2):219-21.
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A combination of antigenic regions of Toxoplasma gondii microneme proteins induces protective immunity against oral infection with parasite cysts.弓形虫微线体蛋白抗原区域的组合可诱导针对寄生虫包囊口服感染的保护性免疫。
J Infect Dis. 2005 Feb 15;191(4):637-45. doi: 10.1086/427660. Epub 2005 Jan 14.
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A heterologous prime-boost vaccination regime using DNA and a vaccinia virus, both expressing GRA4, induced protective immunity against Toxoplasma gondii infection in mice.一种使用均表达GRA4的DNA和痘苗病毒的异源初免-加强免疫方案,可诱导小鼠产生针对刚地弓形虫感染的保护性免疫。
Parasitology. 2007 Sep;134(Pt 10):1339-46. doi: 10.1017/S0031182007002892. Epub 2007 May 17.
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Control of Toxoplasma gondii infection by athymic LEW-Whn rnu rats.无胸腺LEW-Whn rnu大鼠对刚地弓形虫感染的控制
Parasite Immunol. 2008 Jun-Jul;30(6-7):323-33. doi: 10.1111/j.1365-3024.2008.01029.x. Epub 2008 Apr 21.
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Thymus dependency of induced immune responses against Hymenolepis nana (cestode) using congenitally athymic nude mice.利用先天性无胸腺裸鼠研究针对微小膜壳绦虫(绦虫)诱导的免疫反应的胸腺依赖性。
Clin Exp Immunol. 1985 Apr;60(1):87-94.

引用本文的文献

1
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole), pyrimethamine-sulphadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Beverley strain) in mice.复方新诺明(甲氧苄啶-磺胺甲恶唑)、乙胺嘧啶-磺胺嘧啶和螺旋霉素在小鼠感染刚地弓形虫(贝弗利株)无毒株期间的比较效果。
Br J Pharmacol. 1983 Aug;79(4):923-8. doi: 10.1111/j.1476-5381.1983.tb10537.x.