胰岛素治疗对非胰岛素依赖型糖尿病视网膜病变进展的影响。
Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus.
作者信息
Roysarkar T K, Gupta A, Dash R J, Dogra M R
机构信息
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Am J Ophthalmol. 1993 May 15;115(5):569-74. doi: 10.1016/s0002-9394(14)71452-7.
In a six-month prospective study involving 60 noninsulin-dependent diabetics, we evaluated the effect of change to conventional insulin therapy on the pre-existing retinopathy. Ten of 15 patients in group 1 (background or preproliferative diabetic retinopathy treated with insulin) compared to one of 15 patients in group 2 (background or preproliferative diabetic retinopathy treated with hypoglycemic agents) had progression of retinopathy. Worsening of retinopathy was related significantly only to the age of the patients (r = .752, P < .001). None of the 15 patients each in groups 3 and 4 (no retinopathy treated with insulin injections [group 3] or oral hypoglycemic agents [group 4]) developed retinopathy.
在一项为期6个月的前瞻性研究中，我们纳入了60名非胰岛素依赖型糖尿病患者，评估改用常规胰岛素治疗对已存在的视网膜病变的影响。第1组（背景性或增殖前期糖尿病视网膜病变患者接受胰岛素治疗）的15名患者中有10名视网膜病变进展，而第2组（背景性或增殖前期糖尿病视网膜病变患者接受降糖药物治疗）的15名患者中有1名视网膜病变进展。视网膜病变的恶化仅与患者年龄显著相关（r = 0.752，P < 0.001）。第3组和第4组各有15名患者（第3组无视网膜病变患者接受胰岛素注射治疗，第4组无视网膜病变患者接受口服降糖药物治疗）均未出现视网膜病变。
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