抗R质粒药物和伯氨喹的嵌入作用对闭环脱氧核糖核酸超螺旋密度的影响
Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine.
作者信息
Allison R G, Hahn F E
出版信息
Antimicrob Agents Chemother. 1977 Feb;11(2):251-7. doi: 10.1128/AAC.11.2.251.
Abstract
The following compounds, which possess anti-R-plasmid activity (Hahn and Ciak, 1976) in decreasing order, were shown by viscometric titration to change systematically the superhelical density of closed circular PM2 deoxyribonucleic acid in the manner of intercalators: ethidium bromide, quinacrine, acridine orange, quinine, chlorpromazine, chloroquine, and methylene blue. The same effect was caused by the antimalarial drug primaquine, which has not been tested for antiplasmid activity.
摘要
下列具有抗R质粒活性（哈恩和恰克，1976年）且活性依次递减的化合物，通过粘度滴定法表明，它们能以嵌入剂的方式系统地改变闭环PM2脱氧核糖核酸的超螺旋密度：溴化乙锭、喹吖因、吖啶橙、奎宁、氯丙嗪、氯喹和亚甲蓝。抗疟药伯氨喹也产生了同样的效果，不过尚未对其抗质粒活性进行测试。
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