Engel L W
Office of Scientific Review, National Center for Human Genome Research, National Institutes of Health, Bethesda, Md. 20892.
Arch Pathol Lab Med. 1993 May;117(5):459-65.
This article presents an overview of the Human Genome Project. The goals of the program are outlined; the genetic, physical, and DNA sequence maps that will be its products are defined; the brief origins of the project are traced; the management structure of the US Human Genome Project, in which the Department of Energy and the National Institutes of Health participate as partners, is outlined; international dimensions are discussed; the excellent progress to date with respect to each of the eight scientific goals is reported; and the projected impact of the project on biology and medicine is discussed.
本文概述了人类基因组计划。阐述了该计划的目标；定义了将作为其成果的遗传图谱、物理图谱和DNA序列图谱；追溯了该项目的简要起源；概述了美国人类基因组计划的管理结构，能源部和国立卫生研究院作为合作伙伴参与其中；讨论了国际层面的情况；报告了在八项科学目标中的每一项上迄今取得的出色进展；并讨论了该项目对生物学和医学的预期影响。
