Laulumaa V, Kuikka J T, Soininen H, Bergström K, Länsimies E, Riekkinen P
Department of Neurology, Kuopio University Hospital, Finland.
Arch Neurol. 1993 May;50(5):509-12. doi: 10.1001/archneur.1993.00540050059016.
To test the usefulness of single photon emission computed tomography (SPECT) with iodobenzamide in imaging basal ganglia and to elucidate the postulated upward regulation of the striatal D2 dopamine receptors in patients with early Parkinson's disease.
Fourteen patients with Parkinson's disease and eight control subjects were investigated with SPECT using iodobenzamide labeled with iodine 123 as dopamine receptor ligand.
Neurological outpatient service at a university hospital in Kuopio, Finland.
Fourteen patients with recently diagnosed unilateral, unmedicated Parkinson's disease and eight healthy control subjects.
The SPECT images revealed high uptake of iodobenzamide in the basal ganglia. In the patient group, the accumulation was more intense and the iodobenzamide affinity rate was significantly higher in the striatum contralateral to the parkinsonian symptoms. Also, the basal ganglia-cerebellum ratio was higher in the contralateral hemisphere. In the control group, no significant side-to-side differences were observed.
Iodobenzamide with SPECT imaging is useful in evaluating patients with Parkinson's disease. The results also suggest compensatory D2 dopamine receptor upward regulation in the striatum of patients with early unmedicated Parkinson's disease.
检测用碘苯甲酰胺单光子发射计算机断层扫描（SPECT）对基底神经节成像的效用，并阐明早期帕金森病患者纹状体D2多巴胺受体的假定上调情况。
使用以碘123标记的碘苯甲酰胺作为多巴胺受体配体，对14例帕金森病患者和8名对照受试者进行SPECT检查。
芬兰库奥皮奥一所大学医院的神经科门诊。
14例近期诊断为单侧、未用药的帕金森病患者和8名健康对照受试者。
SPECT图像显示基底神经节对碘苯甲酰胺摄取较高。在患者组中，帕金森病症状对侧纹状体的积聚更强烈，碘苯甲酰胺亲和率显著更高。此外，对侧半球的基底神经节 - 小脑比率更高。在对照组中，未观察到明显的左右差异。
碘苯甲酰胺SPECT成像有助于评估帕金森病患者。结果还提示早期未用药帕金森病患者纹状体中存在代偿性D2多巴胺受体上调。
