Salazar Robert D, Moon Kathryn L M, Neargarder Sandy, Cronin-Golomb Alice
Department of Psychological and Brain Sciences, Boston University.
Department of Psychology, Bridgewater State University.
Behav Neurosci. 2019 Aug;133(4):350-360. doi: 10.1037/bne0000329.
Spatial judgment is impaired in Parkinson's disease (PD), with previous research suggesting that disruptions in attention and executive function are likely contributors. If judgment of center places demands on frontal systems, performance on tests of attention/executive function may correlate with extent of bias in PD, and attentional disturbance may predict inconsistency in spatial judgment. The relation of spatial judgment to attention/executive function may differ for those with left-side versus right-side motor onset (LPD, RPD), reflecting effects of attentional lateralization. We assessed 42 RPD, 37 LPD, and 67 healthy control participants with a Landmark task (LM) in which a cursor moved horizontally from the right (right-LM) or left (left-LM). The task was to judge the center of the line. Participants also performed neuropsychological tests of attention and executive function. LM group differences were found on left-LM only, with both PD subgroups biased leftward of the control group (RPD p < .05; LPD p < .01; no RPD-LPD difference). For left-LM trials, extent of bias significantly correlated with performance on the cognitive tasks for PD but not for the control group. PD showed greater variability in perceived center than the control group; this variability correlated with performance on the cognitive tasks. The correlations between performance on the test of spatial judgment and the tests of attention/executive function suggest that frontal-based attentional dysfunction affects dynamic spatial judgment, both in extent of spatial bias and in consistency of response as indexed by intertrial variability. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
帕金森病（PD）患者的空间判断能力受损，先前的研究表明，注意力和执行功能的紊乱可能是导致这一现象的原因。如果对中心位置的判断需要额叶系统的参与，那么注意力/执行功能测试的表现可能与PD患者的偏差程度相关，并且注意力障碍可能预示着空间判断的不一致。空间判断与注意力/执行功能的关系在左侧与右侧运动起病的患者（LPD、RPD）中可能有所不同，这反映了注意力偏侧化的影响。我们使用地标任务（LM）对42名RPD患者、37名LPD患者和67名健康对照参与者进行了评估，在该任务中，光标从右侧（右-LM）或左侧（左-LM）水平移动。任务是判断线条的中心位置。参与者还进行了注意力和执行功能的神经心理学测试。仅在左-LM任务中发现了LM组间差异，两个PD亚组均偏向于对照组的左侧（RPD p < .05；LPD p < .01；RPD与LPD之间无差异）。对于左-LM试验，偏差程度与PD患者认知任务的表现显著相关，但与对照组无关。与对照组相比，PD患者在感知中心位置上表现出更大的变异性；这种变异性与认知任务的表现相关。空间判断测试与注意力/执行功能测试之间的相关性表明，基于额叶的注意力功能障碍会影响动态空间判断，包括空间偏差程度和以试验间变异性为指标的反应一致性。（PsycINFO数据库记录（c）2019美国心理学会，保留所有权利）
