Margolis R L, Andreassen P R
Institut de Biologie Structurale, Grenoble, France.
Bioessays. 1993 Mar;15(3):201-7. doi: 10.1002/bies.950150310.
The molecular signals that determine the position and timing of the furrow that forms during mammalian cell cytokinesis are presently unknown. It is apparent, however, that these signals are generated by the mitotic spindle after the onset of anaphase. Recently we have described a structure that bisects the cell during telophase at the position of the cytokinetic furrow. This structure, the telophase disc, appears to be templated by the mitotic spindle during anaphase, and precedes the formation of the cytokinetic furrow. The relationship of the telophase disc to the myosin and actin based furrowing mechanism is discussed here. We propose that the telophase disc may determine the position and timing of cleavage by recruitment and alignment of myosin.
目前尚不清楚决定哺乳动物细胞胞质分裂过程中形成的沟的位置和时间的分子信号。然而，很明显，这些信号是在后期开始后由有丝分裂纺锤体产生的。最近，我们描述了一种在末期于胞质分裂沟的位置将细胞一分为二的结构。这种结构，即末期盘，似乎在后期由有丝分裂纺锤体形成模板，并先于胞质分裂沟的形成。本文讨论了末期盘与基于肌球蛋白和肌动蛋白的沟形成机制之间的关系。我们提出，末期盘可能通过招募和排列肌球蛋白来决定分裂的位置和时间。
