Satyaswaroop P G
Department of Obstetrics and Gynecology, Milton S. Hershey Medical Center, Hershey, PA 17033.
Ann Med. 1993 Apr;25(2):105-11. doi: 10.3109/07853899309164152.
Endometrial carcinoma is the most common gynaecological malignancy. Progestins are widely used in the treatment of advanced and metastatic disease with about 20-40% response rate. Attempts to develop a predictive test for progestin-sensitivity of endometrial cancers are plagued by the problems of steroid receptor instability and the heterogeneous distribution of progesterone receptor. Successful development of a nude mouse model for human endometrial carcinoma has permitted a detailed investigation of the biological behaviour, hormonal modulation and resistance to progestin therapy. Use of this preclinical model should enhance our understanding of the hormonal mechanisms and lead to improved rational treatment strategies for this malignancy.
子宫内膜癌是最常见的妇科恶性肿瘤。孕激素广泛用于治疗晚期和转移性疾病，有效率约为20%-40%。开发子宫内膜癌孕激素敏感性预测试验的尝试受到类固醇受体不稳定性和孕激素受体分布不均问题的困扰。成功建立人子宫内膜癌裸鼠模型，使得对其生物学行为、激素调节及孕激素治疗耐药性的详细研究成为可能。利用这一临床前模型应能增进我们对激素机制的理解，并为这种恶性肿瘤带来改进的合理治疗策略。
