Redding K G
Arch Dermatol. 1977 Apr;113(4):468-71.
Erythermalgia is a distinctive clinical entity characterized by local redness, warmth, and burning pain in the distal portions of the extremities. In this study, erythemalgia was observed in two patients with myeloproliferative disease. A new theory suggesting abnormally rapid platelet aggregation as a cause of erythermalgia was advanced. The following evidence is presented: (1) histologic evidence of thrombi occluding the arterioles and probably composed of platelet aggregates; (2) reversal of the clinical findings with platelet aggregating drugs, such as heparin sodium and acetylsalicyclic acid; (3) disappearance of the erythemalgia with the adequate control of the myeloproliferative disease.
红斑性肢痛症是一种独特的临床病症，其特征为四肢远端局部发红、发热及灼痛。在本研究中，两名骨髓增殖性疾病患者出现了红斑性肢痛症。有人提出了一种新理论，认为血小板异常快速聚集是红斑性肢痛症的病因。现提供以下证据：（1）组织学证据表明小动脉被血栓阻塞，血栓可能由血小板聚集体构成；（2）使用肝素钠和乙酰水杨酸等血小板聚集药物可使临床症状逆转；（3）随着骨髓增殖性疾病得到充分控制，红斑性肢痛症消失。
