Halme L, Edgren J, von Smitten K, Linden H
Fourth Department of Surgery, University Central Hospital, Helsinki, Finland.
Acta Radiol. 1993 May;34(3):237-41.
Iohexol is a water-soluble contrast medium that is partly absorbed/permeated through mucosa of the small bowel and excreted unchanged in the urine. Iohexol was administered orally to 12 patients with Crohn's disease of the ileum and to 10 healthy controls to measure its excretion in the urine. The location and activity of Crohn's disease were determined by barium double-contrast radiography in all patients and by ileoscopy and biopsy in 9 patients. Iohexol concentrations in serum and 24-hour urine were measured using reversed phase high-performance liquid chromatography. Urinary excretion of iohexol was significantly greater in patients with active Crohn's disease than in controls. We suggest this method as a new way of measuring Crohn's disease activity and mucosal damage in the small bowel. Bowel inflammation and mucosal cell damage are strongly indicated if the iohexol excreted in the urine is over 1% of the oral intake.
碘海醇是一种水溶性造影剂，它可部分通过小肠黏膜吸收/渗透，并以原形经尿液排出。对12例患有回肠克罗恩病的患者和10名健康对照者口服碘海醇，以测定其尿液排泄情况。所有患者均通过钡剂双重造影X线摄影确定克罗恩病的部位和活动情况，9例患者通过回肠镜检查和活检确定。采用反相高效液相色谱法测定血清和24小时尿液中的碘海醇浓度。活动期克罗恩病患者碘海醇的尿排泄量显著高于对照组。我们建议将这种方法作为一种测量小肠克罗恩病活动度和黏膜损伤的新方法。如果尿中排泄的碘海醇超过口服摄入量的1%，则强烈提示肠道炎症和黏膜细胞损伤。
