Aggarwal S K, Fadool J M
Department of Zoology, Michigan State University, East Lansing 48824-1115.
Anticancer Drugs. 1993 Apr;4(2):149-62. doi: 10.1097/00001813-199304000-00004.
Cytochemical and ultrastructural studies in Wistar rats [Crl: (WI)BR] show that cisplatin treatment (5-9 mg/kg) induces a release of neurosecretory granules from the neurohypophysis with a corresponding decrease in the urine output in a time and dose dependent fashion. Cisplatin induces low blood calcium and phosphate levels with a corresponding increase in the dark cells of the parathyroid gland. Injections of calcium before and during the treatment of cisplatin are effective in combating hypocalcemia, nephrotoxicity and gastrointestinal toxicity due to cisplatin. Carboplatin, a less nephrotoxic agent, does not demonstrate any of these changes.
对Wistar大鼠[Crl:(WI)BR]进行的细胞化学和超微结构研究表明，顺铂治疗（5 - 9毫克/千克）会以时间和剂量依赖性方式诱导神经垂体释放神经分泌颗粒，同时尿量相应减少。顺铂会导致血钙和血磷水平降低，甲状旁腺暗细胞相应增加。在顺铂治疗前及治疗期间注射钙，可有效对抗顺铂引起的低钙血症、肾毒性和胃肠道毒性。卡铂是一种肾毒性较小的药物，不会出现上述任何变化。
