Teixeira F
Arch Int Pharmacodyn Ther. 1977 Feb;225(2):221-31.
Removal of adrenaline by the perfused hind-limb of the dog, as well as its accumulation in the femoral artery and saphenous vein, were studied. Saturation of accumulation occurred at the dose level of 1.5 microng/kg.min-1, whereas removal was not saturated at the dose of 4.5 microng/kg.min-1. Removal of adrenaline was significantly reduced by pretreatment with cortexone, cocaine, phenoxybenzamine and reserpine or by surgical denervation of the limb; enzymatic inhibition by iproniazid or U-0521 had no significant effect on removal. Denervation, reserpine and cortex-one blocked the accumulation of adrenaline, whereas U-0521 was the only drug to increase accumulation of adrenaline. The blood vessels perfused have shown a high capacity of removal of adrenaline from the circulating blood, and thus may play an important role in termination of action of both exogenous and adrenal adrenaline.
研究了犬灌注后肢对肾上腺素的清除情况，以及肾上腺素在股动脉和隐静脉中的蓄积情况。在剂量水平为1.5微克/千克·分钟-1时出现蓄积饱和，而在4.5微克/千克·分钟-1的剂量下清除未饱和。用皮质酮、可卡因、苯氧苄胺和利血平预处理或肢体手术去神经支配可显著降低肾上腺素的清除；异烟肼或U - 0521的酶抑制作用对清除无显著影响。去神经支配、利血平和皮质酮可阻断肾上腺素的蓄积，而U - 0521是唯一增加肾上腺素蓄积的药物。所灌注的血管显示出从循环血液中清除肾上腺素的高能力，因此可能在外源性和肾上腺源性肾上腺素作用的终止中起重要作用。
