Afar R, Trifaró J M, Quik M
Department of Pharmacology and Therapeutics, McGill University, Montréal, Canada.
Brain Res. 1993 Mar 26;606(2):346-50. doi: 10.1016/0006-8993(93)91006-e.
Thymopentin is a five amino acid peptide which corresponds to amino acids 32-36 of the thymic polypeptide thymopoietin. Previous work had shown that TP-5 could modulate responsiveness at the muscle-type nicotinic receptor. The present studies show that neuronal nicotinic receptor function, measured as radiolabelled noradrenaline release from bovine adrenal medullary cells, was attenuated by thymopentin. The pentapeptide exhibited specificity for nicotinic receptor evoked release, since thymopentin did not affect potassium-stimulated secretion of [3H]noradrenaline. It appears, therefore, that thymopentin antagonizes catecholamine release by specifically modulating nicotinic receptor responsiveness.
胸腺五肽是一种五氨基酸肽，与胸腺生成素的胸腺多肽的32 - 36位氨基酸相对应。先前的研究表明，TP - 5可调节肌肉型烟碱样受体的反应性。目前的研究表明，以牛肾上腺髓质细胞放射性标记去甲肾上腺素释放量来衡量的神经元烟碱样受体功能，可被胸腺五肽减弱。该五肽对烟碱样受体诱发的释放具有特异性，因为胸腺五肽不影响钾刺激的[³H]去甲肾上腺素分泌。因此，胸腺五肽似乎通过特异性调节烟碱样受体反应性来拮抗儿茶酚胺释放。
