Morzorati S, Kubek M J
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202.
Brain Res Bull. 1993;31(3-4):301-4. doi: 10.1016/0361-9230(93)90221-v.
Regional brain content of TRH was evaluated in selectively bred alcohol-preferring (P) and -nonpreferring (NP) rats before, during, and upon awakening from ethanol sedation. TRH content was significantly lower in both the medial and lateral septum of alcohol-naive P rats compared with alcohol-naive NP rats. Following a sedating dose of ethanol, P rats righted themselves sooner than NP rats. TRH content in the medial septum of P and NP rats was significantly higher when the rats regained their righting reflex. While sedated, TRH in the medial septum of P rats was insignificantly increased. These data are the first to show that endogenous TRH in the medial septum may be involved in arousal from drug-induced sedation and that the events preceding arousal may occur sooner in P than in NP rats. In addition, innate differences in septal TRH may be associated with preference for ethanol.
在选择性培育的嗜酒（P）和不嗜酒（NP）大鼠中，于乙醇镇静前、镇静期间及从乙醇镇静中苏醒时，对其脑内促甲状腺激素释放激素（TRH）的区域含量进行了评估。与未接触乙醇的NP大鼠相比，未接触乙醇的P大鼠内侧和外侧隔区的TRH含量显著更低。给予镇静剂量的乙醇后，P大鼠比NP大鼠更快恢复正常姿势。当大鼠恢复翻正反射时，P大鼠和NP大鼠内侧隔区的TRH含量显著更高。在镇静期间，P大鼠内侧隔区的TRH略有增加。这些数据首次表明，内侧隔区内源性TRH可能参与药物诱导镇静后的觉醒，且P大鼠觉醒前的事件可能比NP大鼠更早发生。此外，隔区TRH的先天差异可能与对乙醇的偏好有关。
