Nikodémová M, Benický J, Brtko J, Strbák V
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Endocrine. 1998 Oct;9(2):213-8. doi: 10.1385/ENDO:9:2:213.
Because chronic ethanol ingestion may perturb thyroid function, we evaluated the effect of 4-wk of oral 10% ethanol ingestion on the hypothalamic-pituitary-thyroid (HPT) axis and septal thyrotropin-releasing hormone (TRH) in 200-g male Wistar rats. Animals were divided into three groups: absolute control receiving tap water and food ad libitum; ethanol group receiving food ad libitum and 10% ethanol as the sole source of drinking fluid; pair-fed group receiving tap water and an amount of food corresponding to the consumption of ethanol group. After 4-wk of treatment, the body weight of the ethanol group was 7% and of the pair-fed rats 19% lower than that of the absolute controls. Both chronic ethanol treatment and food deprivation produced a decrease in plasma thyroid-stimulating hormone (TSH). Pair-fed rats also had a lower plasma T3. Type I iodothyronine 5'-deiodinase activity in the liver was increased in the pair-fed and even more in the ethanol-treated group. The content and secretion in vitro of TRH from the hypothalamic paraventricular nucleus and median eminence were unchanged. TRH content in the septum was increased in both the ethanol and pair-fed groups. TRH secretion from the septum in vitro was lower in the pair-fed, but unchanged in the ethanol group. These data suggest that 4-wk of peroral ethanol intake affects thyroid function mostly at the extrahypothalamic level and that there is a contribution of concomitant food deprivation. Both ethanol treatment and food deprivation increased TRH content in the septum.
由于长期摄入乙醇可能会扰乱甲状腺功能，我们评估了给200克雄性Wistar大鼠口服10%乙醇4周对下丘脑-垂体-甲状腺（HPT）轴及隔区促甲状腺激素释放激素（TRH）的影响。动物被分为三组：绝对对照组，随意饮用自来水和进食；乙醇组，随意进食，饮用10%乙醇作为唯一的液体来源；配对喂养组，饮用自来水，进食量与乙醇组的消耗量相当。治疗4周后，乙醇组的体重比绝对对照组低7%，配对喂养组大鼠的体重比绝对对照组低19%。长期乙醇处理和食物剥夺均导致血浆促甲状腺激素（TSH）降低。配对喂养的大鼠血浆T3也较低。配对喂养组肝脏中的I型碘甲状腺原氨酸5'-脱碘酶活性增加，乙醇处理组增加得更多。下丘脑室旁核和正中隆起的TRH含量及体外分泌未发生变化。乙醇组和配对喂养组隔区的TRH含量均增加。配对喂养组隔区的TRH体外分泌较低，但乙醇组未发生变化。这些数据表明，口服乙醇4周主要在丘脑外水平影响甲状腺功能，同时伴有食物剥夺的作用。乙醇处理和食物剥夺均增加了隔区的TRH含量。
