Lirzin J D, Jorrot J C, Romdhane K, Conseiller C
Département d'anesthésie et de réanimation chirurgicale, Hôpital Cochin-Maternités, Université Paris V.
Cah Anesthesiol. 1993;41(1):23-7.
Sixty patients, undergoing minor gynaecologic procedures, were prospectively enrolled in this randomized study. They were anaesthetized with either propofol or midazolam supplemented or not with fentanyl or alfentanil. Respiratory depression was evaluated using repeated measurements of ventilatory response to CO2 (Read's method) during the preoperative period until the second postoperative hour. No respiratory depression was observed when propofol was used alone. By contrast, midazolam alone induced a significant respiratory depression during the first postoperative hour.
60例行小型妇科手术的患者被前瞻性纳入这项随机研究。她们分别接受丙泊酚或咪达唑仑麻醉，部分加用或不加用芬太尼或阿芬太尼。在术前直至术后第二小时期间，采用重复测量对二氧化碳的通气反应（Read法）来评估呼吸抑制情况。单独使用丙泊酚时未观察到呼吸抑制。相比之下，单独使用咪达唑仑在术后第一小时诱发了显著的呼吸抑制。
