Morley B J, Murphy R
Research Division, Boys Town National Research Hospital, Omaha, Nebraska 68131.
Exp Neurol. 1993 Apr;120(2):277-82. doi: 10.1006/exnr.1993.1061.
It has been suggested that the thymic polypeptide thymopoietin interacts with skeletal muscle nicotinic acetylcholine receptors (nAChRs) and brain nicotinic receptors labeled by alpha-bungarotoxin (alpha-BuTX). In this study, the effects of neonatal thymectomy on the density of skeletal muscle nAChRs and the density of brain alpha-BuTX binding sites at 7 and 45 days postnatal were investigated. In addition, the densities of receptors in the skeletal muscle and brain of the athymic nu/nu mouse at 42 days postnatal were measured. We found little evidence that the absence of the thymus alters the density of nicotinic receptors in either skeletal muscle or brain.
有人提出胸腺多肽促胸腺生成素与骨骼肌烟碱型乙酰胆碱受体（nAChRs）以及被α-银环蛇毒素（α-BuTX）标记的脑烟碱型受体相互作用。在本研究中，我们调查了新生期胸腺切除对出生后7天和45天骨骼肌nAChRs密度以及脑α-BuTX结合位点密度的影响。此外，还测量了出生后42天无胸腺裸鼠骨骼肌和脑中受体的密度。我们几乎没有发现证据表明胸腺缺失会改变骨骼肌或脑中烟碱型受体的密度。
