Joos U, Weingart D, Hoevels S
Department of Oral and Maxillofacial Surgery, University of Münster, Germany.
J Craniomaxillofac Surg. 1993 Apr;21(3):89-92. doi: 10.1016/s1010-5182(05)80170-2.
In an experimental animal study using rabbits, growth phenomena were simulated which are comparable to craniosynostosis in humans. The radiological and histological findings after surgical management of these artificial craniosynostosis by means of strip ostectomy or radical ostectomy were compared with the findings obtained in control animals. Following strip ostectomy, bone defects were rapidly filled by the formation of suture-like structures. After radical ostectomy, structures consisting of connective tissue dispersed among islands of ossification were preserved over a considerable period of time, making it possible for the calvarium to adapt to the fast-growing brain. In contrast to strip ostectomy, after radical ostectomy growth of both the neurocranium and the viscerocranium, as well as the total sagittal growth of the skull, were almost identical to the corresponding growth in the control animals.
在一项使用兔子的实验动物研究中，模拟了与人类颅缝早闭相似的生长现象。通过条带切除术或根治性切除术对这些人工颅缝早闭进行手术治疗后的放射学和组织学结果，与对照动物的结果进行了比较。条带切除术后，骨缺损通过类似缝合结构的形成迅速填充。根治性切除术后，由结缔组织组成的结构分散在骨化岛之间，在相当长的一段时间内得以保留，使颅盖能够适应快速生长的大脑。与条带切除术不同，根治性切除术后，脑颅和面颅的生长以及颅骨的矢状面总生长与对照动物的相应生长几乎相同。
