急性吸入中毒后三氯乙烯从静脉血中消除的动力学

Kinetics of trichloroethylene elimination from venous blood after acute inhalation poisoning.

作者信息

Kostrzewski P, Jakubowski M, Kołaciński Z

机构信息

Department of Toxic Substances Metabolism, Institute of Occupational Medicine, Lódź, Poland.

出版信息

J Toxicol Clin Toxicol. 1993;31(2):353-63. doi: 10.3109/15563659309000403.

DOI:10.3109/15563659309000403

PMID:8492349

Abstract

The kinetics of trichloroethylene were examined in three men, 28-36 years old, hospitalized after an acute occupational exposure. The trichloroethylene concentration of venous blood was determined by gas chromatography with headspace analysis; urinary trichloroacetic acid was assayed by the colorimetric method of Fujiwara. The kinetics of blood trichlorethylene (t1/2 21.7 h) and the urinary elimination of trichloracetic acid over six days were used to calculate the total inhalation exposures. Blood trichlorethylene was diagnostically more relevant than urinary trichloracetic acid.

摘要

对三名28 - 36岁因急性职业暴露而住院的男性进行了三氯乙烯动力学研究。采用顶空气相色谱法测定静脉血中的三氯乙烯浓度；采用藤原比色法测定尿中三氯乙酸。利用血液中三氯乙烯的动力学（半衰期21.7小时）以及六天内尿中三氯乙酸的排泄情况来计算总的吸入暴露量。血液中的三氯乙烯在诊断方面比尿中的三氯乙酸更具相关性。