Le Bouëdec G, Kauffmann P, Richard J F, Le Roux S, Dauplat J
Service de Chirurgie, Centre Jean Perrin, Clermont-Ferrand.
Rev Fr Gynecol Obstet. 1993 Mar;88(3):136-41.
A retrospective series of 34 cases of breast cancer combined with uterine cancer is reported. Cancers of the endometrium differed from cervical cancers by their number, 2.2 x more frequent (22 vs 10) and by the sequence of onset: they generally precede breast cancer, whereas they tend to follow cervical cancers. In contrast to the breast cancer/uterine cervical cancer association, which is considered to be fortuitous, the breast cancer/cancer of the uterine body association appears to be determined by a hormonal context. Through a review of the literature, a unifying endocrine theory is constructed, based on the role of hyperestrogenesis in mammary and endometrial carcinogenesis.
本文报告了一组34例乳腺癌合并子宫癌的回顾性病例。子宫内膜癌与宫颈癌在数量上有所不同,前者的发病频率是后者的2.2倍(22例对10例),且发病顺序也不同:子宫内膜癌通常先于乳腺癌发病,而宫颈癌往往在乳腺癌之后发病。与被认为是偶然发生的乳腺癌/子宫颈癌关联不同,乳腺癌/子宫体癌关联似乎是由激素环境决定的。通过文献综述,基于高雌激素血症在乳腺和子宫内膜致癌作用中构建了一个统一的内分泌理论。