Mulligan R C
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.
Science. 1993 May 14;260(5110):926-32. doi: 10.1126/science.8493530.
The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human disease by gene-based therapies. However, despite substantial progress, a number of key technical issues need to be resolved before gene therapy can be safely and effectively applied in the clinic. Future technological developments, particularly in the areas of gene delivery and cell transplantation, will be critical for the successful practice of gene therapy.
在过去十年中，将基因导入哺乳动物细胞的方法取得了进展，这激发了人们对通过基因疗法治疗人类疾病可能性的极大兴趣。然而，尽管取得了重大进展，但在基因疗法能够安全有效地应用于临床之前，仍有一些关键技术问题需要解决。未来的技术发展，尤其是在基因递送和细胞移植领域，对于基因疗法的成功应用至关重要。
