Krupa D J, Thompson J K, Thompson R F
Neurosciences Program, University of Southern California, Los Angeles 90089.
Science. 1993 May 14;260(5110):989-91. doi: 10.1126/science.8493536.
The localization of sites of memory formation within the brain has proven to be a formidable task even for simple forms of learning and memory. In order to localize a particular site of memory formation within the brain, the rabbit eyeblink response was classically conditioned while regions of the cerebellum or red nucleus were temporarily inactivated by microinfusions of the gamma-aminobutyric acid agonist muscimol. Cerebellar inactivation completely blocked learning but had no effect on subsequent learning after inactivation, whereas red nucleus inactivation did not prevent learning but did block the expression of conditioned responses. The site of memory formation for this learned response thus appears to be localized within the cerebellum.
事实证明，即使对于简单形式的学习和记忆而言，确定大脑中记忆形成的位点也是一项艰巨的任务。为了确定大脑中特定的记忆形成位点，在对兔眨眼反应进行经典条件反射训练的同时，通过微量注射γ-氨基丁酸激动剂蝇蕈醇，暂时使小脑或红核区域失活。小脑失活完全阻断了学习，但在失活后对后续学习没有影响，而红核失活并不妨碍学习，但确实阻断了条件反应的表达。因此，这种习得反应的记忆形成位点似乎定位于小脑内。
