Clark G M
Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio 78284-7884.
Ann N Y Acad Sci. 1993 Mar 20;677:379-83. doi: 10.1111/j.1749-6632.1993.tb38792.x.
The cumulative evidence indicates that flow cytometry can provide important information about the behavior of breast tumors. A particularly appealing aspect of this technology is the ability to determine flow cytometric parameters on fresh surgical samples, frozen biopsy specimens, and archival paraffin-embedded blocks. However, several issues regarding the standardization of tissue preparation and the cell cycle analyses must be addressed before flow cytometry can be routinely applied on a wide scale. Quality control standards are currently being discussed that will help to reduce interlaboratory variability, particularly with respect to absolute values of S-phase fraction.
