半胱氨酸异丙酯及其他半胱氨酸前体对大鼠肺切片中半胱氨酸的升高及谷胱甘肽的补充作用。

Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors.

作者信息

Butterworth M, Upshall D G, Hobbs M, Cohen G M

机构信息

Medical Research Council Toxicology Unit, Carshalton, Surrey, U.K.

出版信息

Biochem Pharmacol. 1993 May 5;45(9):1769-74. doi: 10.1016/0006-2952(93)90432-v.

DOI:10.1016/0006-2952(93)90432-v

PMID:8494535

Abstract

In this study, we have used a rat lung slice model to compare the ability to several potential cysteine delivery systems (L-cysteine isopropylester, L-cysteine cyclohexylester, N-acetylcysteine, L,2-oxo-4-thiazolidine carboxylic acid and cysteine) to elevate cysteine and glutathione (GSH) levels in control lung slices and slices depleted of their GSH by diethyl maleate. The esters of cysteine produced the greatest rise in lung slice cysteine. All the cysteine delivery systems were capable of replenishing GSH in lung slices previously depleted of GSH by diethyl maleate.

摘要

在本研究中，我们使用大鼠肺切片模型来比较几种潜在的半胱氨酸递送系统（L-半胱氨酸异丙酯、L-半胱氨酸环己酯、N-乙酰半胱氨酸、L,2-氧代-4-噻唑烷羧酸和半胱氨酸）在对照肺切片以及用马来酸二乙酯耗尽其谷胱甘肽（GSH）的切片中提高半胱氨酸和谷胱甘肽（GSH）水平的能力。半胱氨酸酯使肺切片中的半胱氨酸升高幅度最大。所有半胱氨酸递送系统都能够在先前用马来酸二乙酯耗尽GSH的肺切片中补充GSH。