吡咯-脒基寡肽的合成与DNA结合选择性
Synthesis and DNA binding selectivity of pyrrole-amidine oligopeptides.
作者信息
Arcamone F
机构信息
Menarini Richerche Sud, Pomezia Rome, Italy.
出版信息
Farmaco. 1993 Feb;48(2):143-50.
PMID:8494595
Abstract
A class of DNA binding antibiotics endowed with antiviral and antitumor properties is reviewed. Starting from the original natural products, namely distamycin and netropsin, new compounds have been recently synthesized with the aim to obtain agents with specific affinity for defined DNA sequences and with different interaction mechanism (reversible or irreversible).
摘要
本文综述了一类具有抗病毒和抗肿瘤特性的DNA结合抗生素。从最初的天然产物，即偏端霉素和纺锤菌素开始，最近合成了新的化合物，目的是获得对特定DNA序列具有特异性亲和力且具有不同相互作用机制（可逆或不可逆）的药物。
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