一些稠合杂环吡咯的合成与抗菌筛选
Synthesis and antimicrobial screening of some fused heterocyclic pyrroles.
作者信息
Mohamed Mousad S, Rashad Aymn E, Zaki Magdy E A, Fatahala Samar S
机构信息
Organic Chemistry Department Faculty of Pharmacy, Helwan University Cairo, Egypt.
出版信息
Acta Pharm. 2005 Sep;55(3):237-49.
PMID:16375835
Abstract
Pyrrole derivatives 1a,b were used as precursors for the preparation of pyrrolo[2,3-d]pyrimidine derivatives 2a,b-7a,b. Also, the formation and structure of different pyrrolotriazolopyrimidine derivatives 8a,b-11a,b were discussed. Some of the prepared products showed potent antimicrobial activity.
摘要
吡咯衍生物1a,b被用作制备吡咯并[2,3 - d]嘧啶衍生物2a,b - 7a,b的前体。此外，还讨论了不同的吡咯并三唑并嘧啶衍生物8a,b - 11a,b的形成和结构。一些制备的产物表现出强效的抗菌活性。
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