次霉素B的光敏作用——一种仅含一个分子内氢键的新型苝醌类色素。
Photosensitization of hypomycin B--a novel perylenequinonoid pigment with only one intramolecular hydrogen bond.
作者信息
Zhang H Y, Liu W, Liu W Z, Xie J L
机构信息
Laboratory for Computational Biology, Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Zibo University, Zibo, People's Republic of China.
出版信息
Photochem Photobiol. 2001 Aug;74(2):191-5. doi: 10.1562/0031-8655(2001)074<0191:pohban>2.0.co;2.
Electron spin resonance technique and spin-trapping methods were used to determine the photoproduction of 1O2 and O2.- by hypomycin B (HMB), a novel perylenequinonoid pigment (PQP) possessing only one hydroxyl group. It was found that the yields of 1O2 and O2.- for HMB were comparable to those for hypocrellin A, a typical natural PQP with good photosensitivity. In addition, the absorption and fluorescence spectra for HMB were investigated. The pKa values in the ground and excited states of HMB were determined to be 8.94 and 5.54, respectively. Thus, the photodynamic mechanisms of HMB may involve not only the photogeneration of 1O2 and O2.- but also the light-induced acidification. Consequently, HMB is proposed to be a good photodynamic therapeutic agent.
采用电子自旋共振技术和自旋捕获方法，测定了仅含一个羟基的新型苝醌类色素（PQP）——次霉素B（HMB）光生成单线态氧（1O2）和超氧阴离子（O2.-）的情况。结果发现，HMB产生1O2和O2.-的产率与具有良好光敏性的典型天然PQP——竹红菌素A相当。此外，还研究了HMB的吸收光谱和荧光光谱。测定出HMB基态和激发态的pKa值分别为8.94和5.54。因此，HMB的光动力机制可能不仅涉及1O2和O2.-的光生成，还涉及光诱导酸化。因此，HMB被认为是一种良好的光动力治疗剂。
Zotero 插件