Lenstra J A
Biochim Biophys Acta. 1977 Mar 28;491(1):333-8. doi: 10.1016/0005-2795(77)90070-8.
Data of 33 proteins are used to compare four methods which predict secondary structure from the amino acid sequence. The prediction of alpha-helices according to the histogram method of Argos et al. (Argos, P., Schwarz, J. and Schwarz, J. (1976) Biochim. Biophys. Acta 439, 261-273) is on the average as reliable as the statistical method of Nagano (Nagano, K. (1973) J. Mol. Biol. 75, 401-420). Both methods predict helices more accurately than the stereo-chemical method of Lim (Lim, V.I. (1974) J. Mol. Biol. 88, 873-894). The method of Nagano yields the best prediction of beta-structure, while the beta-structure predictions of Lim and Argos et al. are not significantly different. The results of the alpha-helix and beta-structure predictions according to the statistical mechanical method of Tanaka and Scheraga (Tanaka, S. and Scheraga, H.A. (1976) Macromolecules 9, 168-182) are inferior to those obtained by the other three methods. For the prediction of turns, no significant difference between the methods of Nagano (Nagano, K. (1974) J. Mol. Biol. 84, 337-372) and Argos et al. was found.
利用33种蛋白质的数据来比较四种从氨基酸序列预测二级结构的方法。根据阿戈斯等人的直方图方法（阿戈斯，P.，施瓦茨，J.和施瓦茨，J.（1976年）《生物化学与生物物理学报》439卷，261 - 273页）对α螺旋的预测，平均而言与长野的统计方法（长野，K.（1973年）《分子生物学杂志》75卷，401 - 420页）一样可靠。这两种方法对螺旋的预测都比林的立体化学方法（林，V.I.（1974年）《分子生物学杂志》88卷，873 - 894页）更准确。长野的方法对β结构的预测效果最佳，而林和阿戈斯等人对β结构的预测没有显著差异。根据田中与谢拉加的统计力学方法（田中，S.和谢拉加，H.A.（1976年）《大分子》9卷，168 - 182页）对α螺旋和β结构的预测结果不如其他三种方法。对于转角的预测，未发现长野（长野，K.（1974年）《分子生物学杂志》84卷，337 - 372页）的方法与阿戈斯等人的方法之间存在显著差异。
