氨氯吡咪对N-甲基-N'-硝基-N-亚硝基胍诱导的Wistar大鼠胃癌发生的抑制作用。
Inhibition by amiloride of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
作者信息
Tatsuta M, Iishi H, Baba M, Uehara H, Nakaizumi A, Taniguchi H
机构信息
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
出版信息
Br J Cancer. 1993 May;67(5):1011-4. doi: 10.1038/bjc.1993.185.
The effects of amiloride on the incidence and histological types of gastric cancers in Wistar rats induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and on the labelling index and proliferative fraction of gastric mucosa were investigated. After oral treatment with MNNG for 25 weeks, rats received s.c. injections of amiloride (0.25 mg kg-1 or 5.0 mg kg-1 body weight) in depot form every other day until the end of the experiment. Prolonged administration of 5.0 mg kg-1, but not 2.5 mg kg-1 of amiloride significantly decreased the incidence of gastric cancers in Week 52. However, it did not influence the histological features of the gastric cancers. It also significantly decreased the labelling index and proliferative fraction of the antral mucosa. These findings indicate that amiloride inhibits the development of gastric cancers, and that its effect may be related to its effect in decreasing cell proliferation of the antral mucosa.
研究了氨氯吡咪对N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的Wistar大鼠胃癌发病率、组织学类型以及胃黏膜标记指数和增殖分数的影响。用MNNG口服处理25周后，大鼠每隔一天接受皮下注射长效制剂形式的氨氯吡咪（0.25 mg/kg或5.0 mg/kg体重），直至实验结束。在第52周时，长期给予5.0 mg/kg而非2.5 mg/kg的氨氯吡咪可显著降低胃癌发病率。然而，它并不影响胃癌的组织学特征。它还显著降低了胃窦黏膜的标记指数和增殖分数。这些发现表明氨氯吡咪可抑制胃癌的发展，其作用可能与其降低胃窦黏膜细胞增殖的作用有关。
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