乙醇对Wistar大鼠中由N-甲基-N'-硝基-N-亚硝基胍诱导的胃癌发生的促进作用。
Promotion by ethanol of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
作者信息
Iishi H, Tatsuta M, Baba M, Taniguchi H
机构信息
Department of Gastrointestinal Oncology, Centre for Adult Diseases, Osaka, Japan.
出版信息
Br J Cancer. 1989 May;59(5):719-21. doi: 10.1038/bjc.1989.151.
The effects of ethanol (EtOH) on the incidence and histology of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in Wistar rats. The animals received alternate-day i.p. injections of 2.5 ml kg-1 body weight of 20% EtOH in 0.9% NaCl solution after 20 weeks of oral treatment with MNNG. Prolonged administration of EtOH resulted in a significant increase in the incidence and number of gastric cancers of the glandular stomach in week 52. However, it had no influence on the histological types of the gastric cancers. Furthermore, it caused a significant increase in the labelling index of the epithelial cells of the antrum in week 52. These findings indicate that EtOH promotes gastric carcinogenesis, and that this effect may be related to its effect in increasing proliferation of the antral epithelial cells.
在Wistar大鼠中研究了乙醇（EtOH）对N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的胃癌发病率和组织学的影响。在用MNNG进行20周口服治疗后，动物每隔一天腹腔注射2.5 ml kg-1体重的20% EtOH于0.9% NaCl溶液中。乙醇的长期给药导致第52周时腺胃胃癌的发病率和数量显著增加。然而，它对胃癌的组织学类型没有影响。此外，它导致第52周时胃窦上皮细胞的标记指数显著增加。这些发现表明乙醇促进胃癌发生，并且这种作用可能与其增加胃窦上皮细胞增殖的作用有关。
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