Weale R
Moorfields Eye Hospital, London.
Br J Ophthalmol. 1993 Apr;77(4):214-7. doi: 10.1136/bjo.77.4.214.
Several lines of research suggest that some systemic diseases, often associated with age-related conditions, may present with enhanced prevalences owing to very early influences on human development. This paper describes an analysis of 1264 adult Caucasian patients presenting either with primary open angle or narrow angle/angle closure glaucoma on the one hand, or with age-related cataract on the other. In addition, data on cataracts and primary open angle glaucoma on 254 patients of Caribbean origin and 190 of south east Asian origin were also examined. Patients were classified with respect to sex and season of birth. These variables can play a statistically significant role in the prevalence of glaucoma, which raises the possibility that environmental influences may be involved.
多项研究表明,一些通常与年龄相关疾病相关的全身性疾病,可能由于对人类发育的早期影响而呈现出更高的患病率。本文描述了对1264名成年白种人患者的分析,这些患者一方面患有原发性开角型或窄角/闭角型青光眼,另一方面患有年龄相关性白内障。此外,还检查了254名加勒比裔患者和190名东南亚裔患者的白内障和原发性开角型青光眼数据。患者按性别和出生季节进行分类。这些变量在青光眼患病率中可能发挥统计学上的显著作用,这增加了环境影响可能参与其中的可能性。