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相似文献

1
The curious case of protein splicing: mechanistic insights suggested by protein semisynthesis.蛋白质剪接的奇特案例：蛋白质半合成所揭示的机制见解
Protein Sci. 1993 May;2(5):697-705. doi: 10.1002/pro.5560020501.
2
Protein splicing: excision of intervening sequences at the protein level.蛋白质剪接：在蛋白质水平上切除居间序列。
Bioessays. 1993 Oct;15(10):667-74. doi: 10.1002/bies.950151006.
3
Protein splicing: its chemistry and biology.蛋白质剪接：其化学与生物学特性
Genes Cells. 1997 Jun;2(6):359-67. doi: 10.1046/j.1365-2443.1997.1270325.x.
4
Protein splicing in the yeast Vma1 protozyme: evidence for an intramolecular reaction.酵母Vma1前体酶中的蛋白质剪接：分子内反应的证据。
FEBS Lett. 1997 Aug 4;412(3):518-20. doi: 10.1016/s0014-5793(97)00850-8.
5
Protein splicing: selfish genes invade cellular proteins.
Curr Opin Cell Biol. 1993 Dec;5(6):971-6. doi: 10.1016/0955-0674(93)90079-6.
6
Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision.酵母TFP1中间蛋白序列的蛋白质剪接：自我切除模型
EMBO J. 1993 Jun;12(6):2575-83. doi: 10.1002/j.1460-2075.1993.tb05913.x.
7
Folding-dependent in vitro protein splicing of the Saccharomyces cerevisiae VMA1 protozyme.酿酒酵母VMA1前体酶的折叠依赖性体外蛋白质剪接
Biochem Biophys Res Commun. 1996 May 24;222(3):827-32. doi: 10.1006/bbrc.1996.0826.
8
Nice splice.拼接得不错。
Nat Struct Biol. 1997 Jul;4(7):507-8. doi: 10.1038/nsb0797-507.
9
Protein-splicing reaction via a thiazolidine intermediate: crystal structure of the VMA1-derived endonuclease bearing the N and C-terminal propeptides.经由噻唑烷中间体的蛋白质剪接反应：携带N端和C端前肽的VMA1衍生核酸内切酶的晶体结构。
J Mol Biol. 2002 Mar 1;316(4):919-29. doi: 10.1006/jmbi.2001.5357.
10
[The discovery and molecular mechanism of protein splicing].
Tanpakushitsu Kakusan Koso. 1997 Nov;42(15):2483-97.

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The Crosstalk Between NETs and the Complement Cascade: An Overview in Nephrological Autoimmune Disease.中性粒细胞胞外陷阱与补体级联反应之间的相互作用：肾脏自身免疫性疾病概述
Int J Mol Sci. 2025 Mar 20;26(6):2789. doi: 10.3390/ijms26062789.
2
Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.一种新型非典型分裂内含肽的结构与生化分析揭示了无半胱氨酸内含肽特有的保守组氨酸。
Chem Sci. 2023 Apr 24;14(19):5204-5213. doi: 10.1039/d3sc01200j. eCollection 2023 May 17.
3
SeqCP: A sequence-based algorithm for searching circularly permuted proteins.SeqCP：一种用于搜索环形排列蛋白质的基于序列的算法。
Comput Struct Biotechnol J. 2022 Nov 14;21:185-201. doi: 10.1016/j.csbj.2022.11.024. eCollection 2023.
4
Mutational analysis of splicing activities of ribonucleotide reductase α subunit protein from lytic bacteriophage P1201.裂殖噬菌体 P1201 的核糖核苷酸还原酶 α 亚基蛋白剪接活性的突变分析。
Curr Microbiol. 2011 Apr;62(4):1282-6. doi: 10.1007/s00284-010-9854-4. Epub 2011 Jan 6.
5
Spontaneous proton transfer to a conserved intein residue determines on-pathway protein splicing.自发质子转移到保守的内含肽残基决定了蛋白内含肽的途径蛋白剪接。
J Mol Biol. 2011 Feb 25;406(3):430-42. doi: 10.1016/j.jmb.2010.12.024. Epub 2010 Dec 23.
6
Conformational modification of serpins transforms leukocyte elastase inhibitor into an endonuclease involved in apoptosis.丝氨酸蛋白酶抑制剂的构象修饰将白细胞弹性蛋白酶抑制剂转化为一种参与细胞凋亡的核酸内切酶。
Mol Cell Biol. 2007 Jun;27(11):4028-36. doi: 10.1128/MCB.01959-06. Epub 2007 Apr 2.
7
Sequence-divergent units of the ABA-1 polyprotein array of the nematode Ascaris suum have similar fatty-acid- and retinol-binding properties but different binding-site environments.猪蛔虫ABA-1多蛋白阵列中序列不同的单元具有相似的脂肪酸和视黄醇结合特性，但结合位点环境不同。
Biochem J. 1999 May 15;340 ( Pt 1)(Pt 1):337-43.
8
A DnaB intein in Rhodothermus marinus: indication of recent intein homing across remotely related organisms.嗜热栖热放线菌中的一种DnaB内含肽：近期内含肽在远缘相关生物体间归巢的证据
Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7851-6. doi: 10.1073/pnas.94.15.7851.
9
The mechanism of protein splicing and its modulation by mutation.蛋白质剪接机制及其突变调控
EMBO J. 1996 Oct 1;15(19):5146-53.
10
Homing events in the gyrA gene of some mycobacteria.一些分枝杆菌gyrA基因中的归巢事件。
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3410-5. doi: 10.1073/pnas.93.8.3410.

本文引用的文献

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Spontaneous re-formation of a broken peptide chain.断裂肽链的自发重新形成。
Nature. 1974 Jan 25;247(5438):202-4. doi: 10.1038/247202a0.
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Implications of the picornavirus capsid structure for polyprotein processing.微小核糖核酸病毒衣壳结构对多聚蛋白加工的影响。
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Protein engineering by chemical means?通过化学方法进行蛋白质工程？
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Selectivity of intracellular proteolysis: protein substrates activate the ATP-dependent protease (La).细胞内蛋白水解的选择性：蛋白质底物激活ATP依赖性蛋白酶（La）。
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Protein engineering of cytochrome c by semisynthesis: substitutions at glutamic acid 66.通过半合成对细胞色素c进行蛋白质工程改造：谷氨酸66位点的替换
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蛋白质剪接的奇特案例：蛋白质半合成所揭示的机制见解

The curious case of protein splicing: mechanistic insights suggested by protein semisynthesis.

作者信息

Wallace C J

机构信息

Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Protein Sci. 1993 May;2(5):697-705. doi: 10.1002/pro.5560020501.

DOI:10.1002/pro.5560020501
PMID:8495192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2142502/
Abstract

The gradual accumulation of examples of protein splicing, in which a nested intervening sequence is spliced out of the interior of a polyprotein precursor, suggests that this curious phenomenon might prove to have universal phylogenetic distribution and biological significance. The known examples are reviewed, with the aim of establishing underlying patterns, and a generalized mechanism of autocatalytic protein splicing is proposed. The testable consequences of such a proposal and the possible evolutionary origins of the phenomenon are discussed.

摘要

蛋白质剪接实例逐渐积累，其中一段嵌套的插入序列从多蛋白前体内部被剪接出来，这表明这种奇特现象可能具有普遍的系统发育分布和生物学意义。本文回顾了已知实例，旨在确立潜在模式，并提出了一种自催化蛋白质剪接的通用机制。讨论了该提议可检验的结果以及该现象可能的进化起源。