Shami S K, Cheatle T R, Chittenden S J, Scurr J H, Coleridge Smith P D
University College and Middlesex School of Medicine, London, UK.
Br J Surg. 1993 Apr;80(4):433-5. doi: 10.1002/bjs.1800800408.
The capacity of the microcirculation in the liposclerotic skin of patients with chronic venous insufficiency to vasodilate in response to pilocarpine electrophoresis was assessed using laser Doppler fluxmetry. Pilocarpine induces vasodilation by direct action on capillaries; other methods of vasodilatation, such as heating of the skin, act by a number of pathways including a neurogenic one. Thirty patients with lipodermatosclerosis and chronic venous insufficiency and 20 control subjects were studied. There was no difference in peak vasodilatation following pilocarpine electrophoresis in the two groups. The median (interquartile range) peak flux in patients was 665 (382-1025) units and in controls 765 (452-975) units (95 per cent confidence interval of difference--270 to 150 units, P = 0.5). This suggests that the capillaries in the liposclerotic skin of patients with chronic venous insufficiency have a normal capacity to vasodilate.
采用激光多普勒血流仪评估慢性静脉功能不全患者脂肪硬化皮肤微循环对毛果芸香碱电泳产生血管舒张反应的能力。毛果芸香碱通过直接作用于毛细血管诱导血管舒张；其他血管舒张方法，如皮肤加热，则通过多种途径起作用，包括神经源性途径。对30例脂肪皮肤硬化症合并慢性静脉功能不全患者和20例对照者进行了研究。两组在毛果芸香碱电泳后血管舒张峰值无差异。患者的峰值通量中位数（四分位间距）为665（382 - 1025）单位，对照组为765（452 - 975）单位（差异的95%置信区间为 - 270至150单位，P = 0.5）。这表明慢性静脉功能不全患者脂肪硬化皮肤中的毛细血管具有正常的血管舒张能力。
